Search results for " Chamomile"
showing 3 items of 3 documents
Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach
2018
Inhibitors of chymase have good potential to provide a novel therapeutic approach for the treatment of cardiovascular diseases. We used a computational approach based on pharmacophore modeling, docking, and molecular dynamics simulations to evaluate the potential ability of 13 natural compounds from chamomile extracts to bind chymase enzyme. The results indicated that some chamomile compounds can bind to the active site of human chymase. In particular, chlorogenic acid had a predicted binding energy comparable or even better than that of some known chymase inhibitors, interacted stably with key amino acids in the chymase active site, and appeared to be more selective for chymase than other …
Effect of Different Green Extraction Methods and Solvents on Bioactive Components of Chamomile (Matricaria chamomilla L.) Flowers
2020
Chamomile (Matricaria chamomilla L.) dried flowers contain a group of interesting biologically active compounds such as sesquiterpenes, flavonoids, coumarins, vitamins, phenolic acids and glucosides. Therefore, the aim of the present study was to characterize the composition in bioactive compounds (specialized metabolites) present in water and ethanol extracts of chamomile flowers, together with monitoring the impact of different extraction techniques (conventional vs. ultrasound-assisted extraction (UAE)) on the parameters under investigation. UAE treatment significantly decreased the extraction time of bioactive compounds from herbal material. Polyphenolic compounds content and antioxidan…
Phenological and agronomical evaluation of chamomile in Mediterranean environments
2008
Chamomile (Chamomilla recutita (L.) Rausch.) is an annual crop, known worldwide as one of the major medicinal herbs. Its flower heads are reported in the official Pharmacopoeia of 26 countries. In order to evaluate the suitability of chamomile to a low-input field cropping management into a semiarid Mediterranean environment, a long-term research activity has been carried out in the experimental farm “Sparacia” (Cammarata – AG – Sicily); hereby we report the results obtained on plants grown in self-seeded experimental plots in 2007/08. Plants development was observed from November 2007 up to (visually assessed) flowers appearance. Blooming started in middle February, and in middle April (af…